Alfacalcidol enhances collagen quality in ovariectomized rat bones
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چکیده
منابع مشابه
Alfacalcidol enhances collagen quality in ovariectomized rat bones
The aim of this study was to investigate the effects of alfacalcidol (1α(OH)D3 : ALF) on bone collagen employing an ovariectomized rat model. Thirty-five 16-week-old female Sprague-Dawley rats were divided into five groups: SHAM (sham-operated + vehicle), OVX (ovariectomy + vehicle), and three ALF-treated groups, that is, ovariectomy + 0.022 µg/kg/day ALF, ovariectomy + 0.067 µg/kg/day ALF, and...
متن کاملCadmium accelerates bone loss in ovariectomized mice and fetal rat limb bones in culture.
Loss of bone mineral after ovariectomy was studied in mice exposed to dietary cadmium at 0.25, 5, or 50 ppm. Results show that dietary cadmium at 50 ppm increased bone mineral loss to a significantly greater extent in ovariectomized mice than in sham-operated controls. These results were obtained from two studies, one in which skeletal calcium content was determined 6 months after ovariectomy a...
متن کاملElectroacupuncture enhances extragonadal aromatization in ovariectomized rats
BACKGROUND Repeated electroacupuncture (EA) stimulation is known to stimulate the activity of the hypothalamus-pituitary-adrenal axis, and to enhance the circulation level of estrogen in the ovariectomized rats. To explore the source of the increased circulation estrogen, the extragonadal aromatization was detected. METHODS Female rats were divided into five groups: 1) intact (INT), 2) intact...
متن کاملEffect of Calcitonin Treatment on Bone Quality and Collagen Structure in Ovariectomized Rats
The aim of this study was to investigate the effect of calcitonin on cortical bone quality and collagen structure at ovariectomized rat model. Forty five Sprague-Dawley female rats were assigned randomly to control group (CON, n=15) ovariectomized group receiving saline only (OVX, n=15), and ovariectomized group receiving salmon calcitonin (i.p.) (OVX-CT, n=15). Thirty rats were anaesthetized w...
متن کاملThe combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis
BACKGROUND We conducted the present study to investigate the therapeutic effects of a combination treatment of alfacalcidol (ALF) and risedronate (RIS) on the bone mechanical properties of bone and calcium (Ca) metabolism using an ovariectomized (OVX) rat model of osteoporosis. METHODS Female Wistar rats were OVX- or sham-operated at 40 weeks of age. Twelve weeks post-surgery, rats were rando...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2014
ISSN: 0736-0266,1554-527X
DOI: 10.1002/jor.22642